In 2009, veterinarians at the U.N. Food and Agriculture Organization made a remarkable announcement: Rinderpest, a livestock-borne disease, would soon be eradicated. OK, so maybe it wasn't front-page news, but rinderpest -- which causes animals to develop fever, followed by diarrhea and (frequently) death -- has over thousands of years been a recurring plague on human civilization. It has destroyed the food supplies of entire countries such as Ethiopia, which lost a third of its population to a rinderpest-related famine in the late 19th century. The FAO's eradication effort, launched in 1992, marks only the second time a disease has been deliberately wiped off the face of the Eearth; the first, better-known case was smallpox, which killed between 300 million and 500 million people over the course of the 20th century before its eradication in 1980.

On June 13, the global community tried for a repeat performance with a pledge drive, held by the Global Alliance for Vaccines and Immunization (GAVI). Thanks to support from aid agencies from Britain to Russia, as well as the Gates Foundation, GAVI raised $4.3 billion to immunize 250 million kids worldwide between now and 2015, protecting against diseases from tetanus to tuberculosis, whooping cough to diphtheria. It's a daunting project, but one that is less implausible than it once was: The range of diseases that can be prevented is growing ever longer, and now includes HPV, rubella, typhoid, and Japanese encephalitis. Vaccines for malaria and dengue fever may not be far behind, and there's even some hope for HIV. GAVI itself boasts a strong track record: Over the organization's first decade, more than 5 million child deaths were prevented though more rapid introduction and increased coverage of vaccines in low-income countries. But, going forward, the alliance is going to have to think more about getting parents to vaccinate their kids -- the demand side of health-- especially if it wants to repeat the huge victory of wiping out a disease.

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Although few in the public-health NGO community would like to admit it, eradicating diseases is at least as dependent on luck as it is on planning and persistence. Universal vaccination -- the only nearly surefire means of eradication -- is an impossibility in most countries. Even the best-resourced campaigns have to deal with the trouble of reaching remote villages over rutted roads to deliver vaccines that sometimes need to be kept refrigerated, often are difficult to administer, and can take multiple shots to take effect. Add to that the challenge of reaching people who often have no official registration or address, and you can see the problem.

Health professionals instead rely on the strategy of trying to vaccinate enough people, especially in the immediate period of an outbreak, so that the disease eventually retreats toward extinction -- always a dicey prospect. Donald Henderson at Johns Hopkins University wrote of smallpox eradication that it "was achieved by only the narrowest of margins" while progress "wavered between success and disaster, often only to be decided by quixotic circumstance or extraordinary performances by field staff."

Today, the world appears to be walking the same knife-edge with polio. The Global Polio Eradication Initiative was launched in 1988 when there were about a third of a million cases worldwide. Indigenous polio was eradicated in the Americas in 1991 and China in 1996. By 1997, the worldwide total of cases was down to 7,000; by 2009, there were only 1,600. But new cases keep popping up: That same year saw outbreaks in Uganda, Mali, Togo, Ghana, Ivory Coast, and Kenya.

The problem wasn't vaccine supply; the world has spent $8.2 billion on eradication programs, which bought both vaccines and the human infrastructure required to deliver them. Rather, it was a demand issue, one that hinged in particular on the attitude of governments and parents.

Take the example of the polio vaccination campaign in northern Nigeria in 2003, which responded to a particularly virulent outbreak that was threatening to spread. The governor of Kano state refused to support the vaccination campaign because of rumors that the vaccines were laced with drugs that would sterilize recipients -- which he claimed was part of a U.S. conspiracy to depopulate the developing world.

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