
Diagnostic devices are big business worldwide. Diagnostic imaging -- tools like X-ray machines and MRIs -- alone accounted for nearly a quarter of global medical-device sales revenues in 2009, to the tune of more than $50 billion. But the tools are designed for rich countries, to be used by skilled technicians to uncover rich-world medical conditions -- which is unsurprising, given that the United States, Germany, Japan, France, Italy, and Britain account for 70 percent of global sales. (Three-quarters of those medical devices that do end up in developing countries do not function and remain unused.) To empower medical consumers in poor countries, diagnostic technologies need to be very simple, hygienic, and cheap. Think of mobile-phone-based eye exams, cholesterol and glucose test strips, and the home pregnancy test.
Diagnostics for All (DFA), a nonprofit medical firm, is working on a range of such simple tests for use in the developing world. Its initial project is designed to spot the side effects of medicines used to treat people with tuberculosis and HIV/AIDS in developing countries. Around a quarter of the 2.8 million people in the developing world on AIDS medications are suffering liver damage as a result, compared with a 2 percent rate in the United States, thanks in large part to more active (but currently expensive) screening after which treatment regimens are changed. The DFA test, targeted to cost 10 cents or less, is a piece of paper that changes color, like a chemistry class pH tester, depending on liver toxicity -- one color indicates the need for closer monitoring, another the need to change the treatment immediately. The company is also developing a test for spoiled milk and an aflatoxin test that will allow farmers to identify crops affected by mold that can cause stunting and liver damage. It will do so at one-twelfth the cost of existing tests.
DFA tests don't require clean water, syringes, refrigeration, lab equipment, or skilled technicians. Users put a drop of blood, urine, or milk on the edge of the paper, and it is wicked to the test material printed on the card, which changes color if the milk is spoiled, the liver is damaged, or the crop has been affected by the mold that produces aflatoxin. They literally blot test material onto paper.
DFA's CEO, Una Ryan, told me that the company is contemplating similar tests for fever and diarrhea. Given the quality of health-care services in many developing countries, that kind of information could be lifesaving. And if it empowers some patients to demand more from their health-care workers, it might play an important role in improving the quality of service provided to everyone else, too.

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